Progressive aphasia with Lewy bodies
Document Type
Article
Abstract
Dementia with Lewy bodies (DLB) may include both Alzheimer and Lewy body pathology, but has never been reported to cause primary progressive aphasia. We report a 69-year-old woman who died 11 years after presenting with the syndrome of progressive aphasia. Six years after aphasia onset she developed visual hallucinations, and subsequently parkinsonism. Autopsy examination revealed Alzheimer's disease (AD), cortical Lewy bodies, and depigmentation and Lewy bodies in the substantia nigra and locus ceruleus. The aphasia most likely reflected the initial onset of AD, and the psychosis and parkinsonism most likely reflected the subsequent onset of Lewy body pathology. This first reported case of progressive aphasia occurring within the context of AD and Lewy body pathology uniquely illustrates the clinical and pathological nosological relationships between these two disease processes, and demonstrates a limitation of the general term, 'DLB'. Copyright © 2002 S. Karger AG, Basel.
Publication Date
12-1-2002
Publication Title
Dementia and Geriatric Cognitive Disorders
ISSN
14208008
Volume
14
Issue
2
First Page
55
Last Page
58
PubMed ID
12145451
Digital Object Identifier (DOI)
10.1159/000064925
Recommended Citation
Caselli, Richard J.; Beach, Thomas G.; Sue, Lucia I.; Connor, Donald J.; and Sabbagh, Marwan N., "Progressive aphasia with Lewy bodies" (2002). Neurology. 1007.
https://scholar.barrowneuro.org/neurology/1007