Furanocoumarins with affinity to brain benzodiazepine receptors in vitro
Eight furanocoumarins were isolated from a methanol extract of dried roots of Angelica dahurica. One of these, phellopterin, strongly (IC = 0.36 μM) inhibits the binding of [ H]diazepam to central nervous system benzodiazepine receptors in vitro, while the others, despite their structural similarities with phellopterin, are considerably less active. 50 3
Digital Object Identifier (DOI)
Bergendorff, Ola; Dekermendjian, Kim; Nielsen, Mogens; Shan, Rudong; Witt, Robin; Ai, Jinglu; and Sterner, Olov, "Furanocoumarins with affinity to brain benzodiazepine receptors in vitro" (1997). Neurobiology. 968.