Valproic acid treatment after experimental subarachnoid hemorrhage
Methods : Mice were randomized to the following experimental groups: SAH, SAH + VPA, Sham, and Sham + VPA. VPA (400 mg/kg) or saline was administered within 30 min of SAH induction and every 12 h thereafter for 48 h. Neurobehavioral assessments using the modifi ed Garcia Score were conducted at 24 and 48 h. Brain injury was assessed at 48 h with fl uoro-jade b and caspase-3/ NeuN histo- and immunohistochemistry. Vasospasm was assessed in the MCA branches using hematoxylin & eosin histology.
Brain injury, Mouse, Neuroprotection, Prechiasmatic injection model, Subarachnoid hemorrhage, Valproic acid
Acta Neurochirurgica, Supplementum
Digital Object Identifier (DOI)
Tso, Michael K.; Lass, Elliot; Ai, Jinglu; and Loch Macdonald, R., "Valproic acid treatment after experimental subarachnoid hemorrhage" (2015). Translational Neuroscience. 925.