Valproic acid treatment after experimental subarachnoid hemorrhage

Document Type

Article

Abstract

Methods : Mice were randomized to the following experimental groups: SAH, SAH + VPA, Sham, and Sham + VPA. VPA (400 mg/kg) or saline was administered within 30 min of SAH induction and every 12 h thereafter for 48 h. Neurobehavioral assessments using the modifi ed Garcia Score were conducted at 24 and 48 h. Brain injury was assessed at 48 h with fl uoro-jade b and caspase-3/ NeuN histo- and immunohistochemistry. Vasospasm was assessed in the MCA branches using hematoxylin & eosin histology.

Keywords

Brain injury, Mouse, Neuroprotection, Prechiasmatic injection model, Subarachnoid hemorrhage, Valproic acid

Publication Date

1-1-2015

Publication Title

Acta Neurochirurgica, Supplementum

ISSN

00651419

E-ISSN

21978395

Volume

120

First Page

81

Last Page

85

PubMed ID

25366604

Digital Object Identifier (DOI)

10.1007/978-3-319-04981-6_14

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