Elevated Expression of a Regulator of the G2/M Phase of the Cell Cycle, Neuronal CIP-1-Associated Regulator of Cyclin B, in Alzheimer's Disease
Document Type
Article
Abstract
Adult neurons are generally accepted to be in a quiescent, nonproliferative state. However, it is becoming increasingly apparent that, in Alzheimer's disease (AD), alterations in cell cycle machinery, suggesting an attempt to reenter cell cycle, relate temporally and topographically to degenerating neurons. These findings, together with the fact that neurons lack the necessary components for completion of mitosis, have led to the notion that an ill-regulated attempt to reenter the cell cycle is associated with disease pathogenesis and, ultimately, neuronal degeneration. To understand better the role of such cell cycle abnormalities in AD, we undertook a study of CIP-1-associated regulator of cyclin B (CARB), a protein that associates with two key proteins, p21 and cyclin B, involved in cellular checkpoints in the cell cycle. Our results show that there are increases in CARB localized to intraneuronal neurofibrillary tangles and granulo-vacuolar degeneration in susceptible hippocampal and cortical neurons in AD. By marked contrast, CARB is found only at background levels in these neuronal populations in nondiseased age-matched controls. Our data not only provide another line of evidence indicative of cell cycle abnormalities in neurons in AD but also lend further credence to the hypothesis that susceptible neurons may be arrested at the G2/M phase of the cell cycle before they die. Therefore, therapeutics targeted toward initiators of the cell cycle are likely to prove of great efficacy for the treatment of AD. © 2004 Wiley-Liss, Inc.
Keywords
Alzheimer's disease, Cell cycle, CIP-1-associated regulator of cyclin B cytoskeleton, Pathogenesis, Phosphorylation, Tau
Publication Date
3-1-2004
Publication Title
Journal of Neuroscience Research
ISSN
03604012
Volume
75
Issue
5
First Page
698
Last Page
703
PubMed ID
14991845
Digital Object Identifier (DOI)
10.1002/jnr.20028
Recommended Citation
Zhu, Xiongwei; McShea, Andrew; Harris, Peggy L.R.; Raina, Arun K.; Castellani, Rudy J.; Funk, Jens Oliver; Shah, Sapan; Atwood, Craig; Bowen, Richard; Bowser, Robert; Morelli, Laura; Perry, George; and Smith, Mark A., "Elevated Expression of a Regulator of the G2/M Phase of the Cell Cycle, Neuronal CIP-1-Associated Regulator of Cyclin B, in Alzheimer's Disease" (2004). Translational Neuroscience. 599.
https://scholar.barrowneuro.org/neurobiology/599