Associations between hepatocyte growth factor, c-Met, and basic fibroblast growth factor and survival in endometrial cancer patients
Document Type
Article
Abstract
Background: Hepatocyte growth factor (HGF), c-Met, and basic fibroblast growth factor (bFGF) are molecular markers that contribute to angiogenesis and proliferation in numerous cancers. We assessed the prognostic significance of these factors in tumour and stroma of endometrial cancer (EC) patients (n=211). Methods: Immunohistochemistry (IHC) was used to detect tumour and stromal protein expression of the biomarkers. Associations between expression and clinicopathological factors were assessed using Chi-square tests. Kaplan-Meier curves, log-rank tests, and Cox regression were used to summarise associations between biomarker expression and overall survival (OS) and recurrence-free survival (RFS). Results: Tumour bFGF was significantly associated with high-grade endometrioid and clear cell histology (P<0.001), advanced stage (P=0.008), positive lymph-node involvement (P=0.002), poor OS (log-rank test, P=0.009), and poor RFS (P<0.001). In multivariable analyses, cases with HGF-positive, stromal bFGF-positive tumours had a lower risk of death compared with cases with HGF-positive, stromal bFGF-negative tumours (hazard ratio (HR): 0.14, 95% CI: 0.03, 0.60). Cases with HGF-positive, bFGF-positive tumours had a higher risk of recurrence compared with cases with negative expression of both markers (HR: 9.88, 95% CI: 2.63, 37.16). Conclusion: These IHC data show that tumour and stromal bFGF expression have opposite associations with survival outcomes in EC patients. If confirmed in larger studies, tumour-derived bFGF could be an attractive target in EC therapy. © 2012 Cancer Research UK All rights reserved.
Keywords
angiogenesis, growth factors, prognostic biomarkers, recurrence-free survival, stroma
Publication Date
6-5-2012
Publication Title
British Journal of Cancer
ISSN
00070920
E-ISSN
15321827
Volume
106
Issue
12
First Page
2004
Last Page
2009
PubMed ID
22617129
Digital Object Identifier (DOI)
10.1038/bjc.2012.200
Recommended Citation
Felix, A. S.; Edwards, R. P.; Stone, R. A.; Chivukula, M.; Parwani, A. V.; Bowser, R.; Linkov, F.; and Weissfeld, J. L., "Associations between hepatocyte growth factor, c-Met, and basic fibroblast growth factor and survival in endometrial cancer patients" (2012). Translational Neuroscience. 557.
https://scholar.barrowneuro.org/neurobiology/557