Role of adenosine in diabetic retinopathy

Authors

Gregory I. Liou, Medical College of Georgia
Saif Ahmad, Medical College of GeorgiaFollow
Mohammad Naime, Medical College of Georgia
Nadeem Fatteh, Medical College of Georgia
Ahmed S. Ibrahim, Mansoura University

Document Type

Article

Abstract

In diabetic retinopathy (DR), abnormalities in vascular and neuronal function are closely related to the local production of inflammatory mediators whose potential source is microglia. Adenosine and its receptors have been shown to possess anti-inflammatory properties that have only recently been studied in DR. Here, we review recent studies that determined the roles of adenosine and its associated proteins, including equilibrative nucleoside transporters, adenosine receptors, and underlying signaling pathways in retinal complications associated with diabetes. © Springer Science+Business Media, LLC 2011.

Keywords

Adenosine, Adenosine receptors, Cannabinoids, Diabetic retinopathy, Microglia

Publication Date

6-1-2011

Publication Title

Journal of Ocular Biology, Diseases, and Informatics

ISSN

19368437

E-ISSN

19368445

Volume

4

Issue

1-2

First Page

19

Last Page

24

Digital Object Identifier (DOI)

10.1007/s12177-011-9067-5

Recommended Citation

Liou, Gregory I.; Ahmad, Saif; Naime, Mohammad; Fatteh, Nadeem; and Ibrahim, Ahmed S., "Role of adenosine in diabetic retinopathy" (2011). Translational Neuroscience. 524.
https://scholar.barrowneuro.org/neurobiology/524