Neuroprotective efficacy of Nardostachys jatamansi and crocetin in conjunction with selenium in cognitive impairment

Document Type

Article

Abstract

Oxidative stress leads to complex biochemical alterations, and has been implicated in the progressive loss of learning and memory. Supplementing and boosting the endogenous antioxidant defense system could impede the progression of various types of neurodegeneration. In the present study, we have investigated the neuroprotective efficacy of a low-dose combination of certain promising and powerful natural antioxidants in an experimental model of cognitive impairment.Combined pretreatmentwith the extract ofNardosatchys jatamansi (N), crocetin (C) and selenium(Se) as sodium selenite (N, 200 mg/kg + C, 25 μg/kg + Se, 0.05 mg/kg body weight) for 15 days led to improved behavioral outcomes in streptozotocin (STZ)-induced cognitive impairment in rats. While intracerebroventricular (ICV) infusion of STZ resulted in the significant elevation ofmarkers of oxidative stress and depletion of endogenous antioxidant defense system in the vehicle-pretreated group, these markers of oxidative stress and antioxidant enzymatic as well as nonenzymatic defense lines were attenuated in the group pretreated with the combination of antioxidants (NCSe). NCSe pretreatment markedly improved the performance of animals in passive avoidance test and Morris water maze (MWM) tasks, significantly reduced the level of TBARS, and elevated the content of glutathione and activities of antioxidant enzymes (glutathione peroxidase, glutathione-S-transferase and catalase).Our study reflects the synergistic potential of the above combination and concludes that amultimodal approach could be beneficial rather than a singular intervention. © Springer-Verlag 2012.

Keywords

Cognitive impairment, Crocetin, Nardostachys jatamansi, Neuroprotection, Oxidative stress, Selenium

Publication Date

10-1-2012

Publication Title

Neurological Sciences

ISSN

15901874

E-ISSN

15903478

Volume

33

Issue

5

First Page

1011

Last Page

1020

PubMed ID

22170092

Digital Object Identifier (DOI)

10.1007/s10072-011-0880-1

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