Intracellular Energy Failure Does Not Underlie Hyperthermic Spreading Depressions In Immature Rat Hippocampal Slice
Hyperthermic spreading depression (HSD) in immature rat hippocampal slices is mediated by Na+/K+-ATPase failure. Here, we test whether depleting intracellular ATP serves as a possible mechanism for HSD genesis. Results indicate that (1) pre-incubation with 3 mM creatine for 3 h failed to prevent hyperthermic spreading depression occurrence; and (2) intracellular ATP concentration doubled during experimental hyperthermia. This study suggests that HSD is not be mediated by depletion of intracellular ATP during hyperthermia. Â© 2003 Elsevier B.V. All rights reserved.
Digital Object Identifier (DOI)
Wu, Jie; Takeo, Teruko; Wakui, Makoto; Ellsworth, Kevin; and Fisher, Robert S., "Intracellular Energy Failure Does Not Underlie Hyperthermic Spreading Depressions In Immature Rat Hippocampal Slice" (2003). Translational Neuroscience. 442.