Intracellular Energy Failure Does Not Underlie Hyperthermic Spreading Depressions In Immature Rat Hippocampal Slice

Authors

Jie Wu, Barrow Neurological InstituteFollow
Teruko Takeo
Makoto Wakui
Kevin Ellsworth
Robert S. Fisher

Department

neurobiology

Document Type

Article

Abstract

Hyperthermic spreading depression (HSD) in immature rat hippocampal slices is mediated by Na+/K+-ATPase failure. Here, we test whether depleting intracellular ATP serves as a possible mechanism for HSD genesis. Results indicate that (1) pre-incubation with 3 mM creatine for 3 h failed to prevent hyperthermic spreading depression occurrence; and (2) intracellular ATP concentration doubled during experimental hyperthermia. This study suggests that HSD is not be mediated by depletion of intracellular ATP during hyperthermia. © 2003 Elsevier B.V. All rights reserved.

Publication Date

10-17-2003

Publication Title

Brain Research

ISSN

00068993

Volume

987

Issue

2

First Page

240

Last Page

243

Digital Object Identifier (DOI)

10.1016/S0006-8993(03)03355-9

Recommended Citation

Wu, Jie; Takeo, Teruko; Wakui, Makoto; Ellsworth, Kevin; and Fisher, Robert S., "Intracellular Energy Failure Does Not Underlie Hyperthermic Spreading Depressions In Immature Rat Hippocampal Slice" (2003). Translational Neuroscience. 442.
https://scholar.barrowneuro.org/neurobiology/442