Title

Roadmap And Standard Operating Procedures For Biobanking And Discovery Of Neurochemical Markers In Als

Department

neurobiology

Document Type

Article

Abstract

Despite major advances in deciphering the neuropathological hallmarks of amyotrophic lateral sclerosis (ALS), validated neurochemical biomarkers for monitoring disease activity, earlier diagnosis, defining prognosis and unlocking key pathophysiological pathways are lacking. Although several candidate biomarkers exist, translation into clinical application is hindered by small sample numbers, especially longitudinal, for independent verification. This review considers the potential routes to the discovery of neurochemical markers in ALS, and provides a consensus statement on standard operating procedures that will facilitate multicenter collaboration, validation and ultimately clinical translation. © 2012 Informa Healthcare.

Publication Date

1-1-2012

Publication Title

Amyotrophic Lateral Sclerosis

ISSN

17482968

Volume

13

Issue

1

First Page

1

Last Page

10

Digital Object Identifier (DOI)

10.3109/17482968.2011.627589

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