Roadmap And Standard Operating Procedures For Biobanking And Discovery Of Neurochemical Markers In Als
Department
neurobiology
Document Type
Article
Abstract
Despite major advances in deciphering the neuropathological hallmarks of amyotrophic lateral sclerosis (ALS), validated neurochemical biomarkers for monitoring disease activity, earlier diagnosis, defining prognosis and unlocking key pathophysiological pathways are lacking. Although several candidate biomarkers exist, translation into clinical application is hindered by small sample numbers, especially longitudinal, for independent verification. This review considers the potential routes to the discovery of neurochemical markers in ALS, and provides a consensus statement on standard operating procedures that will facilitate multicenter collaboration, validation and ultimately clinical translation. © 2012 Informa Healthcare.
Publication Date
1-1-2012
Publication Title
Amyotrophic Lateral Sclerosis
ISSN
17482968
Volume
13
Issue
1
First Page
1
Last Page
10
Digital Object Identifier (DOI)
10.3109/17482968.2011.627589
Recommended Citation
Otto, Markus; Bowser, Robert; Turner, Martin; Berry, James; Brettschneider, Johannes; Connor, James; Costa, Jlia; Cudkowicz, Merit; Glass, Jonathan; Jahn, Olaf; Lehnert, Stefan; Malaspina, Andrea; Parnetti, Lucilla; Petzold, Axel; Shaw, Pamela; Sherman, Alexander; Steinacker, Petra; Sßmuth, Sigurd; Teunissen, Charlotte; Tumani, Hayrettin; Wuolikainen, Anna; and Ludolph, Albert, "Roadmap And Standard Operating Procedures For Biobanking And Discovery Of Neurochemical Markers In Als" (2012). Translational Neuroscience. 36.
https://scholar.barrowneuro.org/neurobiology/36