Correlation of T1- to T2-weighted signal intensity ratio with T1- and T2-relaxation time and IDH mutation status in glioma

Authors

• Takahiro Sanada, Department of Neurosurgery, Asahikawa Medical University, Midorigaoka-Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan.
• Shota Yamamoto, Department of Neurosurgery, Asahikawa Medical University, Midorigaoka-Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan.
• Mio Sakai, Department of Diagnostic and Interventional Radiology, Osaka International Cancer Institute, Osaka, 541-8567, Japan.
• Toru Umehara, Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, 565-0871, Japan.
• Hirotaka Sato, Department of Neurosurgery, Asahikawa Medical University, Midorigaoka-Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan.
• Masato Saito, Department of Neurosurgery, Asahikawa Medical University, Midorigaoka-Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan.
• Nobuyuki Mitsui, Department of Neurosurgery, Asahikawa Medical University, Midorigaoka-Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan.
• Satoru Hiroshima, Department of Neurosurgery, Asahikawa Medical University, Midorigaoka-Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan.
• Ryogo Anei, Department of Neurosurgery, Moriyama Hospital, Asahikawa, 078-8392, Japan.
• Yonehiro Kanemura, Department of Biomedical Research and Innovation, Institute for Clinical Research, National Hospital Organization Osaka National Hospital, Osaka, 540-0006, Japan.
• Mishie Tanino, Department of Diagnostic Pathology, Asahikawa Medical University Hospital, Asahikawa, 078-8510, Japan.
• Katsuyuki Nakanishi, Department of Diagnostic and Interventional Radiology, Osaka International Cancer Institute, Osaka, 541-8567, Japan.
• Haruhiko Kishima, Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, 565-0871, Japan.
• Manabu Kinoshita, Department of Neurosurgery, Asahikawa Medical University, Midorigaoka-Higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan. mail@manabukinoshita.com.

Document Type

Article

Abstract

The current study aimed to test whether the ratio of T1-weighted to T2-weighted signal intensity (T1W/T2W ratio: rT1/T2) derived from conventional MRI could act as a surrogate relaxation time predictive of IDH mutation status in histologically lower-grade gliomas. Strong exponential correlations were found between rT1/T2 and each of T1- and T2-relaxation times in eight subjects (rT1/T2 = 1.63exp + 0.30 and rT1/T2 = 1.27exp + 0.48; R = 0.64 and 0.59, respectively). In a test cohort of 25 patients, mean rT1/T2 (mrT1/T2) was significantly higher in IDHwt tumors than in IDHmt tumors (p < 0.05) and the optimal cut-off of mrT1/T2 for discriminating IDHmt was 0.666-0.677, (AUC = 0.75, p < 0.05), which was validated in an external domestic cohort of 29 patients (AUC = 0.75, p = 0.02). However, this result was not validated in an external international cohort derived from TCIA/TCGA (AUC = 0.63, p = 0.08). The t-Distributed Stochastic Neighbor Embedding analysis revealed a greater diversity in image characteristics within the TCIA/TCGA cohort than in the two domestic cohorts. The failure of external validation in the TCIA/TCGA cohort could be attributed to its wider variety of original imaging characteristics.

Medical Subject Headings

Humans; Glioma (diagnostic imaging, genetics, pathology); Magnetic Resonance Imaging (methods); Mutation; Brain Neoplasms (diagnostic imaging, genetics, pathology); Retrospective Studies; Isocitrate Dehydrogenase (genetics)

Publication Date

11-5-2022

Publication Title

Scientific reports

E-ISSN

2045-2322

Volume

12

Issue

1

First Page

18801

PubMed ID

36335158

Digital Object Identifier (DOI)

10.1038/s41598-022-23527-9

Recommended Citation

Sanada, Takahiro; Yamamoto, Shota; Sakai, Mio; Umehara, Toru; Sato, Hirotaka; Saito, Masato; Mitsui, Nobuyuki; Hiroshima, Satoru; Anei, Ryogo; Kanemura, Yonehiro; Tanino, Mishie; Nakanishi, Katsuyuki; Kishima, Haruhiko; and Kinoshita, Manabu, "Correlation of T1- to T2-weighted signal intensity ratio with T1- and T2-relaxation time and IDH mutation status in glioma" (2022). Translational Neuroscience. 2581.
https://scholar.barrowneuro.org/neurobiology/2581