A pathway map of glutamate metabolism.

Document Type

Article

Abstract

Glutamate metabolism plays a vital role in biosynthesis of nucleic acids and proteins. It is also associated with a number of different stress responses. Deficiency of enzymes involved in glutamate metabolism is associated with various disorders including gyrate atrophy, hyperammonemia, hemolytic anemia, γ-hydoxybutyric aciduria and 5-oxoprolinuria. Here, we present a pathway map of glutamate metabolism representing metabolic intermediates in the pathway, 107 regulator molecules, 9 interactors and 3 types of post-translational modifications. This pathway map provides detailed information about enzyme regulation, protein-enzyme interactions, post-translational modifications of enzymes and disorders due to enzyme deficiency. The information included in the map was based on published experimental evidence reported from mammalian systems.

Publication Date

3-1-2016

Publication Title

J Cell Commun Signal

ISSN

1873-9601

Volume

10

Issue

1

First Page

69

Last Page

75

PubMed ID

26635200

Digital Object Identifier (DOI)

10.1007/s12079-015-0315-5

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