Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis
Document Type
Article
Abstract
Emerging evidence underlines the importance of micro(mi)RNAs in the pathogenesis of multiple sclerosis (MS). Free-circulating miRNAs were investigated in serum from MS patients compared to controls. Statistically significant decreased levels of miR-15b, miR-23a and miR-223 were observed in MS patients (p < 0.05). Results were validated and replicated in two further independent MS populations. A direct correlation between miRNA levels and the EDSS score was determined in PPMS (p < 0.007). The generalized trend toward miRNA down-regulation could result in over-expression of target genes involved in disease pathogenesis. Circulating miRNA profiling could thus represent a new avenue to identify easily detectable disease biomarkers.
Keywords
Multiple sclerosis, biomarkers, demyelination, microRNA, serum
Medical Subject Headings
Adult; Case-Control Studies; Disability Evaluation; Down-Regulation; Female; Genetic Markers; Humans; Male; MicroRNAs (blood); Middle Aged; Multiple Sclerosis, Chronic Progressive (blood, diagnosis, genetics); Multiple Sclerosis, Relapsing-Remitting (blood, diagnosis, genetics); Predictive Value of Tests
Publication Date
12-1-2013
Publication Title
Multiple sclerosis (Houndmills, Basingstoke, England)
E-ISSN
1477-0970
Volume
19
Issue
14
First Page
1938
Last Page
42
PubMed ID
24277735
Digital Object Identifier (DOI)
10.1177/1352458513485654
Recommended Citation
Fenoglio, Chiara; Ridolfi, Elisa; Cantoni, Claudia; De Riz, Milena; Bonsi, Rossana; Serpente, Maria; Villa, Chiara; Pietroboni, Anna M.; Naismith, Robert T.; Alvarez, Enrique; Parks, Becky J.; Bresolin, Nereo; Cross, Anne H.; Piccio, Laura M.; Galimberti, Daniela; and Scarpini, Elio, "Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis" (2013). Translational Neuroscience. 2325.
https://scholar.barrowneuro.org/neurobiology/2325