The complement cascade: new avenues in stroke therapy

Authors

Ricardo J. Komotar, Department of Neurological Surgery, Columbia University, New York, NY 10011, USA. rjk2103@columbia.edu
Robert M. Starke
Eric J. Arias
Matthew C. Garrett
Marc L. Otten
Maxwell B. Merkow
Benjamin Hassid
J Mocco
Michael E. Sughrue
Grace H. Kim
William J. Mack
Andrew F. DucruetFollow
E Sander Connolly

Document Type

Article

Abstract

Recent evidence has shown that after the initial occlusion, a large portion of stroke patients achieve some degree of reperfusion either through collateral circulation or clot dissolution. However, it appears that this reperfusion may lead to increased inflammation-induced damage. Even though the exact mechanism of this secondary injury is unclear, several experimental studies have indicated an intimate connection between complement and this secondary form of damage. We review the available literature and attempt to identify promising clinical therapeutic targets.

Medical Subject Headings

Animals; Brain (physiopathology); Complement Activation (drug effects, physiology); Complement Inactivating Agents (therapeutic use); Disease Models, Animal; Humans; Models, Biological; Neurogenesis (drug effects); Reperfusion Injury (drug therapy, physiopathology); Stroke (complications, drug therapy, physiopathology)

Publication Date

7-1-2009

Publication Title

Current vascular pharmacology

ISSN

1570-1611

Volume

7

Issue

3

First Page

287

Last Page

92

PubMed ID

19601853

Digital Object Identifier (DOI)

10.2174/157016109788340677

Recommended Citation

Komotar, Ricardo J.; Starke, Robert M.; Arias, Eric J.; Garrett, Matthew C.; Otten, Marc L.; Merkow, Maxwell B.; Hassid, Benjamin; Mocco, J; Sughrue, Michael E.; Kim, Grace H.; Mack, William J.; Ducruet, Andrew F.; and Connolly, E Sander, "The complement cascade: new avenues in stroke therapy" (2009). Translational Neuroscience. 2174.
https://scholar.barrowneuro.org/neurobiology/2174