Rich regulates target specificity of photoreceptor cells and N-cadherin trafficking in the drosophila visual system via rab6
Document Type
Article
Abstract
Neurons establish specific synaptic connections with their targets, a process that is highly regulated. Numerous cell adhesion molecules have been implicated in target recognition, but how these proteins are precisely trafficked and targeted is poorly understood. To identify components that affect synaptic specificity, we carried out a forward genetic screen in the Drosophila eye. We identified a gene, named ric1 homologue (rich), whose loss leads to synaptic specificity defects. Loss of rich leads to reduction of N-Cadherin in the photoreceptor cell synapses but not of other proteins implicated in target recognition, including Sec15, DLAR, Jelly belly, and PTP69D. The Rich protein binds to Rab6, and Rab6 mutants display very similar phenotypes as the rich mutants. The active form of Rab6 strongly suppresses the rich synaptic specificity defect, indicating that Rab6 is regulated by Rich. We propose that Rich activates Rab6 to regulate N-Cadherin trafficking and affects synaptic specificity. © 2011 Elsevier Inc.
Publication Date
8-11-2011
Publication Title
Neuron
ISSN
08966273
E-ISSN
10974199
Volume
71
Issue
3
First Page
447
Last Page
459
PubMed ID
21835342
Digital Object Identifier (DOI)
10.1016/j.neuron.2011.06.040
Recommended Citation
Tong, Chao; Ohyama, Tomoko; Tien, An Chi; Rajan, Akhila; Haueter, Claire M.; and Bellen, Hugo J., "Rich regulates target specificity of photoreceptor cells and N-cadherin trafficking in the drosophila visual system via rab6" (2011). Translational Neuroscience. 2010.
https://scholar.barrowneuro.org/neurobiology/2010