Title

Oligodendrocyte precursors migrate along vasculature in the developing nervous system

Document Type

Article

Abstract

Oligodendrocytesmyelinate axons in the central nervous system and develop fromoligodendrocyte precursor cells (OPCs) that must first migrate extensively during brain and spinal cord development.We showthat OPCs require the vasculature as a physical substrate for migration.We observed that OPCs of the embryonic mouse brain and spinal cord, as well as the human cortex, emerge from progenitor domains and associate with the abluminal endothelial surface of nearby blood vessels. Migrating OPCs crawl along and jump between vessels. OPC migration in vivo was disrupted in mice with defective vascular architecture but was normal in mice lacking pericytes. Thus, physical interactions with the vascular endothelium are required for OPC migration.We identifyWnt-Cxcr4 (chemokine receptor 4) signaling in regulation of OPC-endothelial interactions and propose that this signaling coordinates OPC migration with differentiation.

Publication Date

1-22-2016

Publication Title

Science

ISSN

00368075

E-ISSN

10959203

Volume

351

Issue

6271

First Page

379

Last Page

384

PubMed ID

26798014

Digital Object Identifier (DOI)

10.1126/science.aad3839

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