Oligodendrocyte precursors migrate along vasculature in the developing nervous system
Document Type
Article
Abstract
Oligodendrocytesmyelinate axons in the central nervous system and develop fromoligodendrocyte precursor cells (OPCs) that must first migrate extensively during brain and spinal cord development.We showthat OPCs require the vasculature as a physical substrate for migration.We observed that OPCs of the embryonic mouse brain and spinal cord, as well as the human cortex, emerge from progenitor domains and associate with the abluminal endothelial surface of nearby blood vessels. Migrating OPCs crawl along and jump between vessels. OPC migration in vivo was disrupted in mice with defective vascular architecture but was normal in mice lacking pericytes. Thus, physical interactions with the vascular endothelium are required for OPC migration.We identifyWnt-Cxcr4 (chemokine receptor 4) signaling in regulation of OPC-endothelial interactions and propose that this signaling coordinates OPC migration with differentiation.
Publication Date
1-22-2016
Publication Title
Science
ISSN
00368075
E-ISSN
10959203
Volume
351
Issue
6271
First Page
379
Last Page
384
PubMed ID
26798014
Digital Object Identifier (DOI)
10.1126/science.aad3839
Recommended Citation
Tsai, Hui Hsin; Niu, Jianqin; Munji, Roeben; Davalos, Dimitrios; Chang, Junlei; Zhang, Haijing; Tien, An Chi; Kuo, Calvin J.; Chan, Jonah R.; Daneman, Richard; and Fancy, Stephen P.J., "Oligodendrocyte precursors migrate along vasculature in the developing nervous system" (2016). Translational Neuroscience. 2003.
https://scholar.barrowneuro.org/neurobiology/2003