Title

Dynamic expression and cellular localization of the Drosophila 14-3-3ε during embryonic development

Document Type

Article

Abstract

The 14-3-3 protein family is known to interact with various proteins involved in signaling pathways. We report here the expression pattern of the Drosophila 14-3-3 (d14-3-3ε) protein during embryonic development. In syncytial blastoderm when the nuclei divided rapidly, d14-3-3ε localized in the nuclei. During cellularization d14-3-3ε gradually became membrane- bound. During gastrulation, an enhanced staining in the perinuclear region was observed in various tissues. Co-labeling with dp-ERK which recognized the activated form of MAPK suggested that d 14-3-3ε was expressed prior to MAPK activation. During neuronal differentiation, the d14-3-3ε protein remained at a high level in the neuronal cytoplasm.

Keywords

14-3-3, Dp-ERK, Drosophila, Egfr, MAPK, Receptor tyrosine kinase

Publication Date

3-1-1999

Publication Title

Mechanisms of Development

ISSN

09254773

Volume

81

Issue

1-2

First Page

209

Last Page

212

PubMed ID

10330502

Digital Object Identifier (DOI)

10.1016/S0925-4773(98)00238-X

Share

COinS