A notch updated
Document Type
Article
Abstract
Cell - cell signaling mediated by the Notch receptor is iteratively involved in numerous developmental contexts, and its dysregulation has been associated with inherited genetic disorders and cancers. The core components of the signaling pathway have been identifi ed for some time, but the study of the modulation of the pathway in different cellular contexts has revealed many layers of regulation. These include complex sugar modifi cations in the extracellular domain as well as transit of Notch through defi ned cellular compartments, including specifi c endosomes. © 2009 Tien et al.
Publication Date
3-9-2009
Publication Title
Journal of Cell Biology
ISSN
00219525
E-ISSN
00219525
Volume
184
Issue
5
First Page
621
Last Page
629
PubMed ID
19255248
Digital Object Identifier (DOI)
10.1083/jcb.200811141
Recommended Citation
Tien, An Chi; Rajan, Akhila; and Bellen, Hugo J., "A notch updated" (2009). Translational Neuroscience. 1994.
https://scholar.barrowneuro.org/neurobiology/1994