Weight regulation with palatable food and liquids in rats with lateral hypothalamic lesions

Document Type

Article

Abstract

Maintained 25 female Carworth CFE albino rats with 4- or 7-sec 1-ma bilateral lesions of the lateral hypothalamus (LH) for 87 days on a high-fat diet and a sequence of fluids (water, 6% sucrose, and 1 or .2% saccharin). Lesioned Ss reached a greater weight than 9 sham-lesioned Ss offered the same diet and fluids, and maintained greater weight regardless of the fluid offered. These data do not support the hypothesis that LH lesions lower the set point for weight. Rather, the finickiness of LH Ss results in smaller intake of unpalatable foods and water which, in turn, results in stablization of weight below that of controls. If sufficiently hydrated, LH Ss eat greater quantities of highly palatable foods than do controls, resulting in greater body weight. (24 ref.) (PsycINFO Database Record (c) 2006 APA, all rights reserved). © 1972 American Psychological Association.

Keywords

bilateral lesions of lateral hypothalamus, weight regulation with high-fat diet &, saccharin solutions, rats, sucrose &, water &

Publication Date

9-1-1972

Publication Title

Journal of Comparative and Physiological Psychology

ISSN

00219940

Volume

80

Issue

3

First Page

382

Last Page

392

PubMed ID

5071893

Digital Object Identifier (DOI)

10.1037/h0032977

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