Fetal brain transplants: Reduction of cognitive deficits in rats with frontal cortex lesions

Authors

Randy Labbe, Clark University
Arhur Firl, Clark University
Elliott J. Mufson, Beth Israel Deaconess Medical Center
Donald G. Stein, Clark University

Document Type

Article

Abstract

Frontal cortex and cerebellar tissue from fetal rats was implanted into the damaged frontal cortex of adults. Cognitive deficits in spatial alternation learning that follow bilateral destruction of medial frontal cortex were reduced in rats with frontal cortex implants but not in those with implants of cerebellum. Histological evaluation showed that connections were made between the frontal cortex implants and host brain tissue.

Publication Date

1-1-1983

Publication Title

Science

ISSN

00368075

Volume

221

Issue

4609

First Page

470

Last Page

472

PubMed ID

6683427

Digital Object Identifier (DOI)

10.1126/science.6683427

Recommended Citation

Labbe, Randy; Firl, Arhur; Mufson, Elliott J.; and Stein, Donald G., "Fetal brain transplants: Reduction of cognitive deficits in rats with frontal cortex lesions" (1983). Translational Neuroscience. 1808.
https://scholar.barrowneuro.org/neurobiology/1808