Title

Cholinergic and non-cholinergic septohippocampal pathways

Document Type

Article

Abstract

Cholinergic innervation of the hippocampus was examined in the rat by immunocytochemical localization of choline acetyltransferase immunoreactivity combined with retrograde transport of horseradish peroxidase-conjugated wheatgerm agglutinin. It was found that at least 50% of hippocampal afferents arising in the septal-diagonal band region consisted of non-cholinergic projection neurons. In addition, scattered choline acetyltransferase-immunoreactive neurons were localized to the hippocampal formation. These results indicate that: (1) the septohippocampal pathway is neither uniformly nor predominantly cholinergic; and (2) confirm that cholinergic innervation of the hippocampal formation of the rat is derived in part from intrinsic neurons.

Medical Subject Headings

Acetylcholinesterase (metabolism); Animals; Choline O-Acetyltransferase (metabolism); Cholinergic Fibers; Hippocampus (cytology, enzymology); Male; Neural Pathways (cytology, enzymology); Rats; Rats, Inbred Strains; Septum Pellucidum (cytology, enzymology)

Publication Date

2-28-1985

Publication Title

Neuroscience letters

ISSN

0304-3940

Volume

54

Issue

1

First Page

45

Last Page

52

PubMed ID

3974944

Digital Object Identifier (DOI)

10.1016/s0304-3940(85)80116-6

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