Cholinergic and non-cholinergic septohippocampal pathways
Cholinergic innervation of the hippocampus was examined in the rat by immunocytochemical localization of choline acetyltransferase immunoreactivity combined with retrograde transport of horseradish peroxidase-conjugated wheatgerm agglutinin. It was found that at least 50% of hippocampal afferents arising in the septal-diagonal band region consisted of non-cholinergic projection neurons. In addition, scattered choline acetyltransferase-immunoreactive neurons were localized to the hippocampal formation. These results indicate that: (1) the septohippocampal pathway is neither uniformly nor predominantly cholinergic; and (2) confirm that cholinergic innervation of the hippocampal formation of the rat is derived in part from intrinsic neurons.
Medical Subject Headings
Acetylcholinesterase (metabolism); Animals; Choline O-Acetyltransferase (metabolism); Cholinergic Fibers; Hippocampus (cytology, enzymology); Male; Neural Pathways (cytology, enzymology); Rats; Rats, Inbred Strains; Septum Pellucidum (cytology, enzymology)
Digital Object Identifier (DOI)
Wainer, B H.; Levey, A I.; Rye, D B.; Mesulam, M M.; and Mufson, E J., "Cholinergic and non-cholinergic septohippocampal pathways" (1985). Translational Neuroscience. 1742.