Choline acetyltransferase-like immunoreactivity in the forebrain of the red-eared pond turtle (Pseudemys scripta elegans)

Authors

E. J. Mufson, Bullard and Denny-Brown Laboratories and Behavioral Neurology Section of the Harvard Neurology Department and the Charles A Dana Research Institute of the Beth Israel Hospital
P. H. Desan, Harvard Medical School
M. M. Mesulam, Bullard and Denny-Brown Laboratories and Behavioral Neurology Section of the Harvard Neurology Department and the Charles A Dana Research Institute of the Beth Israel Hospital
B. H. Wainer, The University of Chicago
A. I. Levey, The University of Chicago

Document Type

Article

Abstract

Choline acetyltransferase (ChAT) immunohistochemistry was used to map the cholinergic neurons in the forebrain of Pseudemys turtles. Cell bodies with ChAT-like immunoreactivity were seen in the septum, the nucleus of the diagonal band, and embedded within the medial and lateral forebrain bundles. The region of the medial and lateral forebrain bundles contained the greatest concentration of ChAT-positive neurons. Virtually no ChAT-like immunoreactivity was seen in the areas composing the reptilian homologue of the mammalian striatum. It is suggested that the turtle basal forebrain cholinergic neurons may represent the evolutionary precursors to the mammalian cholinergic neurons of the basal forebrain and even the striatum. © 1984.

Keywords

basal forebrain, choline acetyltransferase, cholinergic, immunohistochemistry, turtle

Publication Date

12-3-1984

Publication Title

Brain Research

ISSN

00068993

Volume

323

Issue

1

First Page

103

Last Page

108

PubMed ID

6395936

Digital Object Identifier (DOI)

10.1016/0006-8993(84)90269-5

Recommended Citation

Mufson, E. J.; Desan, P. H.; Mesulam, M. M.; Wainer, B. H.; and Levey, A. I., "Choline acetyltransferase-like immunoreactivity in the forebrain of the red-eared pond turtle (Pseudemys scripta elegans)" (1984). Translational Neuroscience. 1741.
https://scholar.barrowneuro.org/neurobiology/1741