Translational research using a mouse model of intracranial aneurysm

Authors

Kosuke Wada, Department of Anesthesia and Perioperative Care, University of California, San Francisco, 1001 Potrero Avenue, No. 3C-38, San Francisco, CA, 94110, USA.
Hiroshi Makino
Kenji Shimada
Fumiaki Shikata
Atsushi Kuwabara
Tomoki Hashimoto

Document Type

Article

Abstract

We have developed a mouse model of intracranial aneurysm that recapitulates key features of human intracranial aneurysms. In this model, spontaneous aneurysmal rupture occurs with a predictable time course. Aneurysmal rupture in this model can be easily detected by assessing neurological symptoms. Similar to human intracranial aneurysms, intracranial aneurysms in this model show an infiltration with inflammatory cells. This mouse model can be used to study the mechanisms and the potential preventive treatments for aneurysmal rupture.

Medical Subject Headings

Animals; Disease Models, Animal; Intracranial Aneurysm (pathology); Mice; Rupture, Spontaneous (pathology); Translational Research, Biomedical

Publication Date

4-1-2014

Publication Title

Translational stroke research

E-ISSN

1868-601X

Volume

5

Issue

2

First Page

248

Last Page

51

PubMed ID

24323719

Digital Object Identifier (DOI)

10.1007/s12975-013-0296-8

Recommended Citation

Wada, Kosuke; Makino, Hiroshi; Shimada, Kenji; Shikata, Fumiaki; Kuwabara, Atsushi; and Hashimoto, Tomoki, "Translational research using a mouse model of intracranial aneurysm" (2014). Translational Neuroscience. 1705.
https://scholar.barrowneuro.org/neurobiology/1705