Intracranial aneurysms: links among inflammation, hemodynamics and vascular remodeling

Document Type

Article

Abstract

Abnormal vascular remodeling mediated by inflammatory cells has been identified as a key pathologic component of various vascular diseases, including abdominal aortic aneurysms, brain arteriovenous malformations and atherosclerosis. Based on findings from observational studies that analysed human intracranial aneurysms and experimental studies that utilized animal models, an emerging concept suggests that a key component of the pathophysiology of intracranial aneurysms is sustained abnormal vascular remodeling coupled with inflammation. This concept may provide a new treatment strategy to utilize agents to inhibit inflammation or cytokines produced by inflammatory cells such as matrix metalloproteinases. Such an approach would aim to stabilize these vascular lesions and prevent future expansion or rupture.

Medical Subject Headings

Animals; Blood Vessels (physiopathology); Hemodynamics (physiology); Humans; Inflammation (complications, physiopathology); Intracranial Aneurysm (pathology, physiopathology)

Publication Date

6-1-2006

Publication Title

Neurological research

ISSN

0161-6412

Volume

28

Issue

4

First Page

372

Last Page

80

PubMed ID

16759441

Digital Object Identifier (DOI)

10.1179/016164106X14973

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