HIF1A in aortic aneurysms and beyond

Document Type

Article

Abstract

Abdominal aortic aneurysm (AAA) is a permanent expansion of the vessel wall with a high prevalence in those 65 years of age and older. Aneurysms are prone to dissection and rupture that carry a mortality rate of over 85%. Currently, surgical repair is the only option to treat this disease. The need to intervene prior to these events has set off a flurry of basic studies in an effort to understand the cellular and molecular mechanisms that govern AAA formation, progression and rupture. In the present study, the role of myeloid cells in contributing to AAA development has been confirmed. More specifically, the transcription factor, hypoxia-inducible factor-1A (HIF1A), was demonstrated to be a necessary component for regulating the expression of extracellular matrix modifying enzymes and their endogenous inhibitors in these cells. This new discovery may lead to therapeutic targets to prohibit the degradation and weakening of the vessel wall with the hope of limiting AAA formation and/or growth.

Publication Date

4-1-2017

Publication Title

Clinical Science

ISSN

01435221

E-ISSN

14708736

Volume

131

Issue

7

First Page

621

Last Page

623

PubMed ID

28302917

Digital Object Identifier (DOI)

10.1042/CS20160956

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