A mouse model of intracranial aneurysm: Technical considerations
Document Type
Conference Proceeding
Abstract
Intracranial aneurysms can be induced by a single stereotaxic injection of elastase into the cerebrospinal fluid at the right basal cistern in hypertensive mice. This mouse model produces large aneurysm formations with an incidence of 60-80% within 3-4 weeks. Intracranial aneurysms in this model recapitulate key pathological features of human intracranial aneurysms. Several technical factors are critical for the successful induction of intracranial aneurysms in this model. Precise stereotaxic placement of the needle tip into the cerebrospinal fluid space is especially important. Aneurysm formations in this model can serve as a simple and easily interpretable outcome for future studies that utilize various inhibitors, knockout mice, or transgenic mice to test roles of specific molecules and pathways in the pathophysiology of intracranial aneurysms. © 2011 Springer-Verlag/Wien.
Keywords
Animal model, Hypertension, Inflammation, Intracranial aneurysm, Macrophage, Matrix metalloproteinase, Mouse
Publication Date
1-1-2011
Publication Title
Acta Neurochirurgica, Supplementum
ISSN
00651419
E-ISSN
00016268
ISBN
9783709106921
Issue
111
First Page
31
Last Page
35
PubMed ID
21725728
Digital Object Identifier (DOI)
10.1007/978-3-7091-0693-8_6
Recommended Citation
Tada, Yoshiteru; Kanematsu, Yasuhisa; Kanematsu, Miyuki; Nuki, Yoshitsugu; Liang, Elena I.; Wada, Kosuke; Makino, Hiroshi; and Hashimoto, Tomoki, "A mouse model of intracranial aneurysm: Technical considerations" (2011). Translational Neuroscience. 1655.
https://scholar.barrowneuro.org/neurobiology/1655