Neural Stem Cells Sustain Natural Killer Cells That Dictate Recovery From Brain Inflammation

Department

neurobiology

Document Type

Article

Abstract

Recovery from organ-specific autoimmune diseases largely relies on the mobilization of endogenous repair mechanisms and local factors that control them. Natural killer (NK) cells are swiftly mobilized to organs targeted by autoimmunity and typically undergo numerical contraction when inflammation wanes. We report the unexpected finding that NK cells are retained in the brain subventricular zone (SVZ) during the chronic phase of multiple sclerosis in humans and its animal model in mice. These NK cells were found preferentially in close proximity to SVZ neural stem cells (NSCs) that produce interleukin-15 and sustain functionally competent NK cells. Moreover, NK cells limited the reparative capacity of NSCs following brain inflammation. These findings reveal that reciprocal interactions between NSCs and NK cells regulate neurorepair.

Publication Date

1-27-2016

Publication Title

Nature Neuroscience

ISSN

10976256

Volume

19

Issue

2

First Page

243

Last Page

252

Digital Object Identifier (DOI)

10.1038/nn.4211

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