Estrogen receptor alpha containing neurons in the monkey forebrain: Lack of association with calcium binding proteins and choline acetyltransferase
Document Type
Article
Abstract
The present study used single and dual immunohistochemistry to determine the topography and chemical phenotype of ERα containing neurons within the monkey forebrain utilizing antibodies directed against the full-length human ERα (NCL-ER-6F11), calcium-binding proteins calbindin-D28k, and parvalbumin as well as choline acetyltransferase (ChAT). Our findings demonstrate for the first time ERα immunoreactive (-ir) cells in the monkey cerebral cortex (layers I-II) and in the claustrum. In addition, ERα-ir cells were seen in the septum, basal forebrain, amygdala and hypothalamus. Double-labeled cells for ERα and calbindin-D28k were seen only in the ventrolateral part of the ventromedial hypothalamic nucleus. In contrast, the co-localization of ERα and parvalbumin or ChAT was not seen in any of the areas of the monkey forebrain examined. These observations suggest that estrogens, at least in part, via ERα regulate calbindin-D28k hypothalamic but not parvalbumin or ChAT containing neurons in select monkey forebrain regions. © 2004 Elsevier B.V. All rights reserved.
Keywords
Brain, Calbindin, Cholinergic, Estrogen, Immunohistochemistry, Neurotransmitters, modulators, transporters, receptors, Parvalbumin, Regional localization of receptors and transmitters
Publication Date
9-3-2004
Publication Title
Brain Research
ISSN
00068993
Volume
1019
Issue
1-2
First Page
55
Last Page
63
PubMed ID
15306238
Digital Object Identifier (DOI)
10.1016/j.brainres.2004.05.101
Recommended Citation
Perez, Sylvia; Sendera, T. J.; Kordower, J. H.; and Mufson, E. J., "Estrogen receptor alpha containing neurons in the monkey forebrain: Lack of association with calcium binding proteins and choline acetyltransferase" (2004). Translational Neuroscience. 1625.
https://scholar.barrowneuro.org/neurobiology/1625