Distribution of galaninergic immunoreactivity in the brain of the mouse
Document Type
Article
Abstract
The distribution of galaninergic immunoreactive (-ir) profiles was studied in the brain of colchicine-pretreated and non-pretreated mice. Galanin (GAL)-ir neurons and fibers were observed throughout all encephalic vesicles. Telencephalic GAL-ir neurons were found in the olfactory bulb, cerebral cortex, lateral and medial septum, diagonal band of Broca, nucleus basalis of Meynert, bed nucleus of stria terminalis, amygdala, and hippocampus. The thalamus displayed GAL-ir neurons within the anterodorsal, paraventricular, central lateral, paracentral, and central medial nuclei. GAL-ir neurons were found in several regions of the hypothalamus. In the midbrain, GAL-ir neurons appeared in the pretectal olivary nucleus, oculomotor nucleus, the medial and lateral lemniscus, periaqueductal gray, and the interpeduncular nucleus. The pons contained GAL-ir neurons within the dorsal subcoeruleus, locus coeruleus, and dorsal raphe. In the medulla oblongata, GAL-ir neurons appear in the anterodorsal and dorsal cochlear nuclei, salivatory nucleus, A5 noradrenergic cells, gigantocellular nucleus, inferior olive, solitary tract nucleus, dorsal vagal motor and hypoglossal nuclei. Only GAL-ir fibers were seen in the lateral habenula nucleus, substantia nigra, parabrachial complex, cerebellum, spinal trigeminal tract, as well as the motor root of the trigeminal and facial nerves. GAL-ir was also observed in several circumventricular organs. The widespread distribution of galanin in the mouse brain suggests that this neuropeptide plays a role in the regulation of cognitive and homeostatic functions. © 2001 Wiley-Liss, Inc.
Keywords
Central nervous system, Galanin, Immunohistochemistry, Mouse, Neuropeptide
Publication Date
5-28-2001
Publication Title
Journal of Comparative Neurology
ISSN
00219967
Volume
434
Issue
2
First Page
158
Last Page
185
PubMed ID
11331523
Digital Object Identifier (DOI)
10.1002/cne.1171
Recommended Citation
Pérez, Silvia E.; Wynick, David; Steiner, Robert A.; and Mufson, Elliott J., "Distribution of galaninergic immunoreactivity in the brain of the mouse" (2001). Translational Neuroscience. 1621.
https://scholar.barrowneuro.org/neurobiology/1621