Olig2-Regulated Lineage-Restricted Pathway Controls Replication Competence in Neural Stem Cells and Malignant Glioma
Document Type
Article
Abstract
Recent studies have identified stem cells in brain cancer. However, their relationship to normal CNS progenitors, including dependence on common lineage-restricted pathways, is unclear. We observe expression of the CNS-restricted transcription factor, OLIG2, in human glioma stem and progenitor cells reminiscent of type C transit-amplifying cells in germinal zones of the adult brain. Olig2 function is required for proliferation of neural progenitors and for glioma formation in a genetically relevant murine model. Moreover, we show p21WAF1/CIP1, a tumor suppressor and inhibitor of stem cell proliferation, is directly repressed by OLIG2 in neural progenitors and gliomas. Our findings identify an Olig2-regulated lineage-restricted pathway critical for proliferation of normal and tumorigenic CNS stem cells. © 2007 Elsevier Inc. All rights reserved.
Keywords
HUMDISEASE, MOLNEURO, STEMCELL
Publication Date
2-15-2007
Publication Title
Neuron
ISSN
08966273
Volume
53
Issue
4
First Page
503
Last Page
517
PubMed ID
17296553
Digital Object Identifier (DOI)
10.1016/j.neuron.2007.01.009
Recommended Citation
Ligon, Keith L.; Huillard, Emmanuelle; Mehta, Shwetal; Kesari, Santosh; Liu, Hongye; Alberta, John A.; Bachoo, Robert M.; Kane, Michael; Louis, David N.; DePinho, Ronald A.; Anderson, David J.; Stiles, Charles D.; and Rowitch, David H., "Olig2-Regulated Lineage-Restricted Pathway Controls Replication Competence in Neural Stem Cells and Malignant Glioma" (2007). Translational Neuroscience. 1592.
https://scholar.barrowneuro.org/neurobiology/1592