Mapping Single-Cell-Substrate Interactions By Surface Plasmon Resonance Microscopy

Department

neurobiology

Document Type

Article

Abstract

We report the imaging of the cell-substrate adhesion of a single cell with subcellular spatial resolution. Osmotic pressure was introduced to provide a controllable mechanical stimulation to the cell attached to a substrate, and high-resolution surface plasmon resonance microscopy was used to map the response of the cell, from which local cell-substrate adhesion was determined. In addition to high spatial resolution, the approach is noninvasive and fast and allows for the continuous mapping of cell-substrate interactions and single-cell movements. © 2012 American Chemical Society.

Publication Date

9-18-2012

Publication Title

Langmuir

ISSN

07437463

Volume

28

Issue

37

First Page

13373

Last Page

13379

Digital Object Identifier (DOI)

10.1021/la301712h

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