RNA knockdown as a potential therapeutic strategy in Parkinson's disease

Document Type

Article

Abstract

Parkinson's disease is a prevalent progressive degenerative disorder of the elderly. There is a current need for novel therapeutic strategies because the standard levodopa pharmacotherapy is only temporarily efficacious. Recently, there have been some high-profile successful preclinical results obtained in animal models of neurological disorders using small interfering RNAs delivered by viral vectors. RNA interference can theoretically be applied to Parkinson's disease since over-expression of various proteins is known to kill the dopamine neurons of the substantia nigra in animal models and in familial forms of Parkinson's disease. Potential RNA interfering strategies and caveats are discussed in this review. © 2006 Nature Publishing Group All rights reserved.

Publication Date

3-1-2006

Publication Title

Gene Therapy

ISSN

09697128

E-ISSN

14765462

Volume

13

Issue

6

First Page

517

Last Page

524

PubMed ID

16267570

Digital Object Identifier (DOI)

10.1038/sj.gt.3302669

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