NF-κB signaling in skeletal muscle health and disease
Document Type
Book
Abstract
Muscle development, growth, and maintenance require an intricate and timely series of events initiated through a multitude of signaling pathways. The very nature of skeletal muscle requires tremendous plasticity to accommodate the need for anabolism or catabolism, and deregulation of these processes may be a tipping point in the development or progression of various skeletal muscle disorders. Among the relevant signaling pathways, NF-κB has emerged as a critical factor involved in various facets of muscle homeostasis. In this review, we summarize the NF-κB signaling pathway and provide a fresh perspective into the regulation and function of this transcription factor, underlying both the physiological and pathophysiological states of skeletal muscle. © 2011 Elsevier Inc.
Keywords
Atrophy, Cachexia, IKK, Muscular dystrophy, Myogenesis, NF-κB, Skeletal muscle, Stress
Publication Date
5-30-2011
Publication Title
Current Topics in Developmental Biology
ISSN
00702153
Volume
96
First Page
85
Last Page
119
PubMed ID
21621068
Digital Object Identifier (DOI)
10.1016/B978-0-12-385940-2.00004-8
Recommended Citation
Peterson, Jennifer M.; Bakkar, Nadine; and Guttridge, Denis C., "NF-κB signaling in skeletal muscle health and disease" (2011). Translational Neuroscience. 1397.
https://scholar.barrowneuro.org/neurobiology/1397