Title

RNA editing deficiency in neurodegeneration

Document Type

Article

Abstract

The molecular process of RNA editing allows changes in RNA transcripts that increase genomic diversity. These highly conserved RNA editing events are catalyzed by a group of enzymes known as adenosine deaminases acting on double-stranded RNA (ADARs). ADARs are necessary for normal development, they bind to over thousands of genes, impact millions of editing sites, and target critical components of the central nervous system (CNS) such as glutamate receptors, serotonin receptors, and potassium channels. Dysfunctional ADARs are known to cause alterations in CNS protein products and therefore play a role in chronic or acute neurodegenerative and psychiatric diseases as well as CNS cancer. Here, we review how RNA editing deficiency impacts CNS function and summarize its role during disease pathogenesis.

Keywords

5HT receptors, AMPA, Cancer, Excitotoxicity, GluA2, K channels, MARCH, Neurodegeneration, Psychiatric diseases, RNA editing

Publication Date

1-1-2018

Publication Title

Advances in Neurobiology

ISSN

21905215

Volume

20

First Page

63

Last Page

83

PubMed ID

29916016

Digital Object Identifier (DOI)

10.1007/978-3-319-89689-2_3

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