RNA editing deficiency in neurodegeneration
Document Type
Article
Abstract
The molecular process of RNA editing allows changes in RNA transcripts that increase genomic diversity. These highly conserved RNA editing events are catalyzed by a group of enzymes known as adenosine deaminases acting on double-stranded RNA (ADARs). ADARs are necessary for normal development, they bind to over thousands of genes, impact millions of editing sites, and target critical components of the central nervous system (CNS) such as glutamate receptors, serotonin receptors, and potassium channels. Dysfunctional ADARs are known to cause alterations in CNS protein products and therefore play a role in chronic or acute neurodegenerative and psychiatric diseases as well as CNS cancer. Here, we review how RNA editing deficiency impacts CNS function and summarize its role during disease pathogenesis.
Keywords
5HT receptors, AMPA, Cancer, Excitotoxicity, GluA2, K channels, MARCH, Neurodegeneration, Psychiatric diseases, RNA editing
Publication Date
1-1-2018
Publication Title
Advances in Neurobiology
ISSN
21905215
Volume
20
First Page
63
Last Page
83
PubMed ID
29916016
Digital Object Identifier (DOI)
10.1007/978-3-319-89689-2_3
Recommended Citation
Lorenzini, Ileana; Moore, Stephen; and Sattler, Rita, "RNA editing deficiency in neurodegeneration" (2018). Translational Neuroscience. 1386.
https://scholar.barrowneuro.org/neurobiology/1386