SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways

Authors

Ines Batinic-Haberle, Duke University School of Medicine
Artak Tovmasyan, Duke University School of Medicine
Emily R.H. Roberts, Duke University School of Medicine
Zeljko Vujaskovic, Duke University School of Medicine
Kam W. Leong, Duke University School of Medicine
Ivan Spasojevic, Duke University School of Medicine

Document Type

Article

Abstract

SIGNIFICANCE: Superoxide dismutase (SOD) enzymes are indispensable and ubiquitous antioxidant defenses maintaining the steady-state levels of O2·(-); no wonder, thus, that their mimics are remarkably efficacious in essentially any animal model of oxidative stress injuries thus far explored.

Publication Date

5-20-2014

Publication Title

Antioxidants & redox signaling

E-ISSN

15577716

Volume

20

Issue

15

First Page

2372

Last Page

2415

PubMed ID

23875805

Digital Object Identifier (DOI)

10.1089/ars.2012.5147

Recommended Citation

Batinic-Haberle, Ines; Tovmasyan, Artak; Roberts, Emily R.H.; Vujaskovic, Zeljko; Leong, Kam W.; and Spasojevic, Ivan, "SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways" (2014). Translational Neuroscience. 1293.
https://scholar.barrowneuro.org/neurobiology/1293