Effect of molecular characteristics on cellular uptake, subcellular localization, and phototoxicity of Zn(2) N-Alkylpyridylporphyrins

Authors

Rima Ezzeddine, Kuwait University
Anwar Al-Banaw, Kuwait University
Artak Tovmasyan, Duke University Medical Center
James D. Craik, Kuwait University
Ines Batinic-Haberle, Duke University Medical Center
Ludmil T. Benov, Kuwait University

Document Type

Article

Abstract

Background: Delivering molecules to selected cellular compartments is important for analytical and practical purposes. Results: Varying the length and positions of alkyl substituents results in preferential uptake of zinc porphyrins by particular cellular structures. Conclusion: Uptake, distribution, and phototoxicity of porphyrins depend on charge, lipophilicity, and molecular shape. Significance: Systematic chemical modification provides the basis for rational design of molecules targeting specific cellular compartments. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

Publication Date

12-20-2013

Publication Title

Journal of Biological Chemistry

ISSN

00219258

E-ISSN

1083351X

Volume

288

Issue

51

First Page

36579

Last Page

36588

PubMed ID

24214973

Digital Object Identifier (DOI)

10.1074/jbc.M113.511642

Recommended Citation

Ezzeddine, Rima; Al-Banaw, Anwar; Tovmasyan, Artak; Craik, James D.; Batinic-Haberle, Ines; and Benov, Ludmil T., "Effect of molecular characteristics on cellular uptake, subcellular localization, and phototoxicity of Zn(2) N-Alkylpyridylporphyrins" (2013). Translational Neuroscience. 1266.
https://scholar.barrowneuro.org/neurobiology/1266