Mosaic organization of neural stem cells in the adult brain

Authors

Florian T. Merkle, Department of Neurosurgery and Developmental and Stem Cell Biology Program, University of California, San Francisco, San Francisco, CA 94143-0525, USA.
Zaman Mirzadeh
Arturo Alvarez-Buylla

Document Type

Article

Abstract

The in vivo potential of neural stem cells in the postnatal mouse brain is not known, but because they produce many different types of neurons, they must be either very versatile or very diverse. By specifically targeting stem cells and following their progeny in vivo, we showed that postnatal stem cells in different regions produce different types of neurons, even when heterotopically grafted or grown in culture. This suggests that rather than being plastic and homogeneous, neural stem cells are a restricted and diverse population of progenitors.

Medical Subject Headings

Adult Stem Cells (cytology); Animals; Animals, Newborn; Astrocytes (cytology); Brain (cytology); Cell Differentiation; Cells, Cultured; Interneurons (cytology); Lateral Ventricles (cytology); Mice; Neuroglia (cytology); Neurons (cytology); Olfactory Bulb (cytology); Stem Cell Transplantation; Transplantation, Heterotopic

Publication Date

7-20-2007

Publication Title

Science (New York, N.Y.)

E-ISSN

1095-9203

Volume

317

Issue

5836

First Page

381

Last Page

4

PubMed ID

17615304

Digital Object Identifier (DOI)

10.1126/science.1144914

Recommended Citation

Merkle, Florian T.; Mirzadeh, Zaman; and Alvarez-Buylla, Arturo, "Mosaic organization of neural stem cells in the adult brain" (2007). Translational Neuroscience. 1239.
https://scholar.barrowneuro.org/neurobiology/1239