Title

Timing relationships for secondary ischemia in rodents: the effect of venous obstruction.

Department

Neurosurgery

Document Type

Article

Abstract

In a previous study, timing relationships were studied for flaps subjected to secondary ischemia by total pedicle interruption. In the current paper, using a rodent epigastric flap, a similar study for flaps subjected to secondary ischemia by venous obstruction was performed. These conditions were designed to mimic a venous thrombosis following flap transfer, as would be performed clinically. In Experiment 1, the time interval between primary and secondary ischemia was varied. When the interval was 72 hr, flaps with secondary ischemia had similar survival to those with primary ischemia. However, when the time interval was 24 hr, flap survival after secondary ischemia was significantly worse than after primary ischemia (p less than 0.01). In Experiment 2, the duration of primary ischemia was varied (15 min, 30 min or 1.5 hr), prior to a fixed interval between primary and secondary ischemia and 5 hr of secondary ischemia. These conditions produced significantly more necrosis than 5 hr of primary ischemia. Thus, even short periods of primary ischemia may have detrimental effects on flap survival after a subsequent period of secondary ischemia. This may have important clinical ramifications.

Medical Subject Headings

Animals; Graft Survival; Ischemia; Male; Necrosis; Rats; Rats, Inbred Strains; Surgical Flaps; Thrombosis; Time Factors

Publication Date

3-1-1992

Publication Title

Journal of reconstructive microsurgery

ISSN

0743-684X

Volume

8

Issue

2

First Page

107

Last Page

109

PubMed ID

1564681

Digital Object Identifier (DOI)

10.1055/s-2007-1006692

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