Timing relationships for secondary ischemia in rodents: the effect of arteriovenous obstruction.
The first ischemic insult a tissue suffers is primary (1 degree) ischemia. A second ischemic episode, such as thrombosis after free tissue transfer, may be regarded as secondary (2 degrees) ischemia. Timing relationships were studied in a rodent epigastric-flap model. In a first experiment, the interval between 1 degree ischemia and 2 degrees ischemia was varied. Flaps which had 2 degrees ischemia 12 and 36 hr after the 1 degree episode, had decreased ischemic tolerance, compared with 1 degree ischemic flaps; 2 degrees ischemic flaps, after an interval of 72 hr, had an ischemic tolerance similar to 1 degree ischemic flaps. In a second experiment, the length of the 1 degree ischemia was varied. It was found that as little as 5 min of 1 degree ischemia significantly decreased the subsequent tolerance of 2 degrees ischemia. The possible clinical significance of these results is discussed.
Medical Subject Headings
Animals; Graft Survival; Ischemia; Male; Rats; Rats, Inbred Strains; Skin; Surgical Flaps; Thrombosis; Time Factors
Journal of reconstructive microsurgery
Digital Object Identifier (DOI)
Angel, M F; Knight, K R; Biavati, M J; Mellow, C G; Wanebo, John E; Amiss, L R; and Morgan, R M, "Timing relationships for secondary ischemia in rodents: the effect of arteriovenous obstruction." (1991). Neurosurgery. 696.