The dorsal rat flap: a discussion of the model and the salutary effect of cimetidine on flap survival.
Failure of skin flaps remains a significant clinical problem. The dorsal rat flap, a reliable experimental model, was used to test the efficacy of cimetidine in treating a failing flap. Flaps were elevated in 45 rats divided into three equal groups. Group 1 was a saline control group, Group 2 received cimetidine 250 mg/kg three times a day for 7 days postoperatively, and Group 3 received cimetidine for 1 day before surgery, and then as in Group 2. Necrosis was assessed on the seventh postoperative day. Group 2 had 31.1 +/- 1.3 (mean % +/- SEM) necrosis, significantly better than saline control animals (p less than 0.01) and pretreated animals (p less than 0.05). These results suggest the usefulness of cimetidine in ischemic flap surgery.
Medical Subject Headings
Animals; Cimetidine; Disease Models, Animal; Injections, Intraperitoneal; Male; Necrosis; Postoperative Complications; Rats; Rats, Inbred Strains; Surgical Flaps; Tissue Survival
Otolaryngology and head and neck surgery
5 ( Pt 1)
Digital Object Identifier (DOI)
Angel, M F; Wanebo, John E; Bardakjian, V; Amiss, L R; and Morgan, R F, "The dorsal rat flap: a discussion of the model and the salutary effect of cimetidine on flap survival." (1990). Neurosurgery Articles. 695.