Stereotactic Laser Ablation as Treatment for Brain Metastases That Recur After Stereotactic Radiosurgery: A Multiinstitutional Experience
Objective Therapeutic options for brain metastases (BMs) that recur after stereotactic radiosurgery (SRS) remain limited. Methods The authors provide the collective experience of 4 institutions where treatment of BMs that recurred after SRS was performed with stereotactic laser ablation (SLA). Results Twenty-six BMs (in 23 patients) that recurred after SRS were treated with SLA (2 patients each underwent 2 SLAs for separate lesions, and a third underwent 2 serial SLAs for discrete BMs). Histological findings in the BMs treated included the following: breast (n = 6); lung (n = 6); melanoma (n = 5); colon (n = 2); ovarian (n = 1); bladder (n = 1); esophageal (n = 1); and sarcoma (n = 1). With a median follow-up duration of 141 days (range 64-794 days), 9 of the SLA-treated BMs progressed despite treatment (35%). All cases of progression occurred in BMs in which < 80% ablation was achieved, whereas no disease progression was observed in BMs in which â‰¥ 80% ablation was achieved. Five BMs were treated with SLA, followed 1 month later by adjuvant SRS (5 Gy daily Ã— 5 days). No disease progression was observed in these patients despite ablation efficiency of < 80%, suggesting that adjuvant hypofractionated SRS enhances the efficacy of SLA. Of the 23 SLA-treated patients, 3 suffered transient hemiparesis (13%), 1 developed hydrocephalus requiring temporary ventricular drainage (4%), and 1 patient who underwent SLA of a 28.9-cm3 lesion suffered a neurological deficit requiring an emergency hemicraniectomy (4%). Although there is significant heterogeneity in corticosteroid treatment post-SLA, most patients underwent a 2-week taper. Conc lusions Stereotactic laser ablation is an effective treatment option for BMs in which SRS fails. Ablation of = 80% of BMs is associated with decreased risk of disease progression. The efficacy of SLA in this setting may be augmented by adjuvant hypofractionated SRS.
Digital Object Identifier (DOI)
Ali, Mir Amaan; Carroll, Kate T.; Rennert, Robert C.; Hamelin, Thomas; Chang, Leon; Lemkuil, Brian P.; Sharma, Mayur; Barnholtz-Sloan, Jill S.; Myers, Charlotte; Barnett, Gene H.; Smith, Kris A.; Mohammadi, Alireza M.; Sloan, Andrew E.; and Chen, Clark C., "Stereotactic Laser Ablation as Treatment for Brain Metastases That Recur After Stereotactic Radiosurgery: A Multiinstitutional Experience" (2016). Neurosurgery. 391.