Radiopathologic predictors of recurrence in patients with a gross totally resected atypical meningioma

Authors

Sharath Kumar Anand, School of Medicine, Wayne State University, Detroit, MI, USA.
Hamid Sardari, Student Research Committee, Clinical Research Development Center, Taleghani and Imam Ali Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Alireza Sadeghsalehi, Department of Pathology, Kermanshah University of Medical Sciences, Taleghani Hospital, Kermanshah, Iran.
Seyed Reza Bagheri, Neurosurgery Department of Neurosurgery, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Sonia V. Eden, School of Medicine, Wayne State University, Detroit, MI, USA.
Michael T. Lawton, Neurosurgery, Department of Neurological Surgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.Follow
Ehsan Alimohammadi, Neurosurgery Department of Neurosurgery, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Document Type

Article

Abstract

BACKGROUND: Atypical meningiomas (AM) comprise a heterogeneous conglomeration of meningiomas with higher local recurrence rates than their benign counterparts. Although adjuvant therapy following subtotal resection is the standard, the use of adjuvant therapy following gross total resection (GTR) remains controversial. This study seeks to add to the literature by identifying radiopathologic predictors of recurrence in patients with a GTR AM and better identify those patients who may benefit from adjuvant therapy. METHODS: A total of 103 consecutive patients who received gross total resection for AM at our center between Apr 2010 and Apr 2019 were evaluated retrospectively. Recurrence was defined as new enhancing masses on MRI without requiring biopsy confirmation. Cumulative incidence plots were used to estimate survival, and the log-rank test was used to assess differences between groups. Cox proportional hazards models were used to evaluate the effect of radiopathologic variables on the hazard of recurrence. RESULTS: Of the 103 patients included in this study, 68 (66.0%) were female, and the mean age was 51.1 ± 11.4. The median overall survival for patients following surgery was 71 months while the median progression-free survival was 64 months. Recurrence occurred in 36 (35.0%) patients. Factors correlated with AM recurrence following GTR included peritumoral edema (p = 0.005), necrosis (p < 0.001), mitotic rate greater than 7/10 high-power field (HPF) (p < 0.001), and Ki67 > 15% (p < 0.001). However, following Cox proportional hazards regression analysis, only mitotic rate greater than 7/10HPF (p = 0.018) and Ki67 > 15% (p = 0.035) were significantly associated with AM recurrence. CONCLUSIONS: Our results showed high mitotic index (greater than 7/10 HPF) and Ki67 greater than 15% as independent predictors of recurrence in patients with a GTR AM. These findings could help stratify patients who may benefit from adjuvant therapy.: AM: Atypical meningiomas; GTR: gross total resection; HPF: high power field; STR: subtotal resection; RFS: recurrence-free survival.

Medical Subject Headings

Adult; Female; Humans; Kaplan-Meier Estimate; Ki-67 Antigen; Male; Meningeal Neoplasms (diagnostic imaging, radiotherapy, surgery); Meningioma (diagnostic imaging, radiotherapy, surgery); Middle Aged; Neoplasm Recurrence, Local (diagnostic imaging, surgery); Radiotherapy, Adjuvant (methods); Retrospective Studies

Publication Date

5-1-2022

Publication Title

Neurological research

E-ISSN

1743-1328

Volume

44

Issue

5

First Page

468

Last Page

474

PubMed ID

34967283

Digital Object Identifier (DOI)

10.1080/01616412.2021.2022915

Recommended Citation

Anand, Sharath Kumar; Sardari, Hamid; Sadeghsalehi, Alireza; Bagheri, Seyed Reza; Eden, Sonia V.; Lawton, Michael T.; and Alimohammadi, Ehsan, "Radiopathologic predictors of recurrence in patients with a gross totally resected atypical meningioma" (2022). Neurosurgery. 1589.
https://scholar.barrowneuro.org/neurosurgery/1589