Pearls and Pitfalls of Quantitative Software Analysis of Dopamine Transporter SPECT
Document Type
Article
Abstract
Dopamine transporter SPECT with I-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) nortropane (I-ioflupane) aids in the diagnosis of parkinsonian syndrome by demonstrating loss of striatal dopamine transporters, proportional to nigrostriatal dopaminergic neuronal loss. Quantitative software analysis (QSA) is a helpful adjunct to visual interpretation. An atlas of pearls and pitfalls of QSA is presented. Examples include correction for head tilt/orientation, scaling artifacts, and detection of balanced loss of activity. Additional examples are provided where QSA can potentially fail such as patient variation and vascular disease.
Medical Subject Headings
Aged; Artifacts; Dopamine Plasma Membrane Transport Proteins (metabolism); Female; Humans; Image Processing, Computer-Assisted (methods); Male; Middle Aged; Nortropanes; Parkinsonian Disorders (diagnostic imaging, metabolism); Software; Tomography, Emission-Computed, Single-Photon
Publication Date
11-1-2020
Publication Title
Clinical nuclear medicine
E-ISSN
1536-0229
Volume
45
Issue
11
First Page
e469
Last Page
e476
PubMed ID
32701796
Digital Object Identifier (DOI)
10.1097/RLU.0000000000003183
Recommended Citation
Mushtaq, Raza; Kay, Matthew D.; Steinmeyer, Laura; Warhadpande, Devdutta; and Kuo, Phillip H., "Pearls and Pitfalls of Quantitative Software Analysis of Dopamine Transporter SPECT" (2020). Neuroradiology. 70.
https://scholar.barrowneuro.org/neuroradiology/70