Pearls and Pitfalls of Quantitative Software Analysis of Dopamine Transporter SPECT

Authors

Raza Mushtaq, From the Department of Medical Imaging, University of Arizona College of Medicine.Follow
Matthew D. Kay, From the Department of Medical Imaging, University of Arizona College of Medicine.
Laura Steinmeyer, From the Department of Medical Imaging, University of Arizona College of Medicine.
Devdutta Warhadpande, From the Department of Medical Imaging, University of Arizona College of Medicine.
Phillip H. Kuo

Document Type

Article

Abstract

Dopamine transporter SPECT with I-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) nortropane (I-ioflupane) aids in the diagnosis of parkinsonian syndrome by demonstrating loss of striatal dopamine transporters, proportional to nigrostriatal dopaminergic neuronal loss. Quantitative software analysis (QSA) is a helpful adjunct to visual interpretation. An atlas of pearls and pitfalls of QSA is presented. Examples include correction for head tilt/orientation, scaling artifacts, and detection of balanced loss of activity. Additional examples are provided where QSA can potentially fail such as patient variation and vascular disease.

Medical Subject Headings

Aged; Artifacts; Dopamine Plasma Membrane Transport Proteins (metabolism); Female; Humans; Image Processing, Computer-Assisted (methods); Male; Middle Aged; Nortropanes; Parkinsonian Disorders (diagnostic imaging, metabolism); Software; Tomography, Emission-Computed, Single-Photon

Publication Date

11-1-2020

Publication Title

Clinical nuclear medicine

E-ISSN

1536-0229

Volume

45

Issue

11

First Page

e469

Last Page

e476

PubMed ID

32701796

Digital Object Identifier (DOI)

10.1097/RLU.0000000000003183

Recommended Citation

Mushtaq, Raza; Kay, Matthew D.; Steinmeyer, Laura; Warhadpande, Devdutta; and Kuo, Phillip H., "Pearls and Pitfalls of Quantitative Software Analysis of Dopamine Transporter SPECT" (2020). Neuroradiology. 70.
https://scholar.barrowneuro.org/neuroradiology/70