Vascular risk profile and white matter hyperintensity volume among Mexican Americans and non-Hispanic Whites: The HABLE study

Authors

Kevin S. King, Department of Neuroradiology Barrow Neurological Institute Phoenix Arizona USA.Follow
Raul M. Vintimilla, Institute for Translational Research University of North Texas Health Science Center Fort Worth Texas USA.
Meredith N. Braskie, Imaging Genetics Center Keck School of Medicine USC Stevens Neuroimaging and Informatics Institute Los Angeles California USA.
Ke Wei, Department of Computer Science University of Southern California Los Angeles California USA.
James R. Hall, Institute for Translational Research University of North Texas Health Science Center Fort Worth Texas USA.
Matt Borzage, Research Pediatrics Children's Hospital of Los Angeles Keck School of Medicine USC Los Angeles California USA.
Leigh A. Johnson, Institute for Translational Research University of North Texas Health Science Center Fort Worth Texas USA.
Kristine Yaffe, Department of Psychiatry, Neurology, and Epidemology and Biostatistics University of California San Francisco California USA.
Arthur W. Toga, Laboratory of Neuro Imaging USC Stevens Neuroimaging and Informatics Institute Keck School of Medicine of USC University of Southern California Los Angeles California USA.
Sid E. O'Bryant, Institute for Translational Research University of North Texas Health Science Center Fort Worth Texas USA.

Document Type

Article

Abstract

INTRODUCTION: Among vascular risk factors we hypothesized that an increased prevalence of diabetes in Hispanics would be associated with greater white matter hyperintensity (WMH) volume, which may contribute to cognitive decline. METHODS: A total of 1318 participants (60% female; 49% Hispanic, 51% non-Hispanic White; age 66.2 ± 8.9 years) underwent clinical evaluation and brain magnetic resonance imaging (MRI). WMH volume associations were assessed with age, sex, and ethnicity and then with vascular risk factors in a selective regression model. RESULTS: WMH volume was greater with older age ( < .0001), Hispanic ethnicity ( = .02), and female sex ( = .049). WMH volume was best predicted by age, diastolic blood pressure, hypertension history, hemoglobin A1c (HbA1c), white blood cell count, and hematocrit ( < .01 for all). Elevated HbA1c was associated with greater WMH volume among Hispanics (parameter estimate 0.08 ± 0.02, < .0001) but not non-Hispanic Whites (parameter estimate 0.02 ± 0.04, = .5). DISCUSSION: WMH volume was greater in Hispanics, which may be partly explained by increased WMH volume related to elevated HbA1c among Hispanics but not non-Hispanic Whites.

Publication Date

1-1-2022

Publication Title

Alzheimer's & dementia (Amsterdam, Netherlands)

ISSN

2352-8729

Volume

14

Issue

1

First Page

e12263

PubMed ID

35229016

Digital Object Identifier (DOI)

10.1002/dad2.12263

Recommended Citation

King, Kevin S.; Vintimilla, Raul M.; Braskie, Meredith N.; Wei, Ke; Hall, James R.; Borzage, Matt; Johnson, Leigh A.; Yaffe, Kristine; Toga, Arthur W.; and O'Bryant, Sid E., "Vascular risk profile and white matter hyperintensity volume among Mexican Americans and non-Hispanic Whites: The HABLE study" (2022). Neuroradiology. 62.
https://scholar.barrowneuro.org/neuroradiology/62