Epileptic pilocarpine-treated rats exhibit aberrant hippocampal EPSP-spike potentiation but retain long-term potentiation.
Document Type
Article
Abstract
Hippocampal neuron plasticity is strongly associated with learning, memory, and cognition. In addition to modification of synaptic function and connectivity, the capacity of hippocampal neurons to undergo plasticity involves the ability to change nonsynaptic excitability. This includes altering the probability that EPSPs will generate action potentials (E-S plasticity). Epilepsy is a prevalent neurological disorder commonly associated with neuronal hyperexcitability and cognitive dysfunction. We examined E-S plasticity in chronically epileptic Sprague-Dawley rats 3-10 weeks after pilocarpine-induced
Medical Subject Headings
Action Potentials; Animals; Electric Stimulation; Epilepsy, Temporal Lobe; Excitatory Postsynaptic Potentials; Hippocampus; Long-Term Potentiation; Muscarinic Agonists; Neuronal Plasticity; Pilocarpine; Rats, Sprague-Dawley; Status Epilepticus
Publication Date
11-1-2017
Publication Title
Physiol Rep
ISSN
2051-817X
Volume
5
Issue
21
PubMed ID
29138358
Digital Object Identifier (DOI)
10.14814/phy2.13490
Recommended Citation
Carpenter-Hyland, Ezekiel; Bichler, Edyta K; Smith, Mathew V; Sloviter, Robert S; and Benveniste, Morris, "Epileptic pilocarpine-treated rats exhibit aberrant hippocampal EPSP-spike potentiation but retain long-term potentiation." (2017). Neuroradiology. 109.
https://scholar.barrowneuro.org/neuroradiology/109