Epileptic pilocarpine-treated rats exhibit aberrant hippocampal EPSP-spike potentiation but retain long-term potentiation.

Document Type

Article

Abstract

Hippocampal neuron plasticity is strongly associated with learning, memory, and cognition. In addition to modification of synaptic function and connectivity, the capacity of hippocampal neurons to undergo plasticity involves the ability to change nonsynaptic excitability. This includes altering the probability that EPSPs will generate action potentials (E-S plasticity). Epilepsy is a prevalent neurological disorder commonly associated with neuronal hyperexcitability and cognitive dysfunction. We examined E-S plasticity in chronically epileptic Sprague-Dawley rats 3-10 weeks after pilocarpine-induced

Medical Subject Headings

Action Potentials; Animals; Electric Stimulation; Epilepsy, Temporal Lobe; Excitatory Postsynaptic Potentials; Hippocampus; Long-Term Potentiation; Muscarinic Agonists; Neuronal Plasticity; Pilocarpine; Rats, Sprague-Dawley; Status Epilepticus

Publication Date

11-1-2017

Publication Title

Physiol Rep

ISSN

2051-817X

Volume

5

Issue

21

PubMed ID

29138358

Digital Object Identifier (DOI)

10.14814/phy2.13490

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