Apolipoprotein E genotypes in Parkinson's disease with and without dementia

Document Type

Article

Abstract

The apolipoprotein E gene (Apo E) type 4 allele is a genetic risk factor influencing the development and age of onset of Alzheimer's disease. Because Parkinson's disease shares many characteristics of Alzheimer's disease, we studied the frequencies of Apo E genotypes in a cohort of 52 Parkinson's disease patients with dementia and 61 patients without dementia. Dementia was determined per National Institute of Neurological and Communicative Disorders and Stroke criteria and Mattis Dementia Rating Scale (DRS) < 126. Normal cognition was defined as DRS > 132. Apo E genotype and allele frequencies did not differ between demented and nondemented parkinsonian patients. Neither group's genotype and allele frequencies differed from that of a nondemented population of 78 controls. We conclude that the Apo E ε4 allele influences neither the development of Parkinson's disease nor the dementia associated with Parkinson's disease nor the dementia associated with Parkinson's disease. Copyright © 1995 American Neurological Association

Publication Date

1-1-1995

Publication Title

Annals of Neurology

ISSN

03645134

E-ISSN

15318249

Volume

37

Issue

2

First Page

242

Last Page

245

PubMed ID

7847865

Digital Object Identifier (DOI)

10.1002/ana.410370215

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